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Arthur Harden
1865–1940 · United Kingdom · Born in the 1800s
Nobel Chemistry 1929
British biochemist who showed that alcoholic fermentation by yeast juice needs both enzymes and a small-molecule coenzyme, opening the study of metabolic intermediates.
Nobel Prize work
Shared with Hans von Euler-Chelpin for investigations of sugar fermentation and fermentative enzymes. Harden separated yeast juice into an enzyme fraction and a dialysable 'coferment' (coenzyme), identified inorganic phosphate as essential, and traced phosphorylated sugar intermediates — key steps toward mapping glycolysis.
Fields
Related topics
Enzymes and enzyme kinetics
Enzymes accelerate reactions by lowering the activation free-energy barrier; they do not change the equilibrium constant.
Metabolism (glycolysis, Krebs cycle, electron transport chain)
Metabolism is a network of linked reactions that captures energy and supplies building blocks; ATP and reduced cofactors connect pathways.